A public competition for the new metropolitan chapel was announced in 1814 and the building went up between 1814 and 1825, before Catholic Emancipation. The winning drawings were signed only with the letter P, and the question of who really designed the church has never been settled. Daniel O'Connell attended a thanksgiving Mass here in 1829 after Emancipation, and in 1847 his body lay in state in the church for four days before burial in Glasnevin. Michael Collins received a state funeral here in 1922. The Palestrina Choir, endowed by Edward Martyn, was installed in 1903, and the tenor John McCormack sang in it in 1904 and 1905. Alterations followed for the centenary of Catholic Emancipation in 1928 and the Eucharistic Congress of 1932. In November 2025, two hundred years after its dedication, the church finally became St Mary's Cathedral.
Mother church of the Archdiocese; home of the Palestrina Choir.
Constituted 14 November 1825. Parishes of St Mary's and St Francis Xavier, Gardiner Street, merged July 2024.